PneumoniaResearchNetwork onGeneticResistance and Susceptibility for the EvolutionofSevereSepsis
PROGRESS is a research project which unites activities from three networks funded by the Federal Ministry for Education and Research (BMBF):
CAPNETZ- Network of Excellence Community Acquired Pneumonia
SepNet – Competence Network Sepsis
NGFN – National Genome research network “Infection and Inflammation”
PROGRESS is also funded by the BMBF in the framework of the “Health Research: Research for Humankind” programme.
The main aim of PROGRESS is to identify transcriptom and proteom based signatures and biomarkers and genetic polymorphisms which are associated with community acquired pneumonia and its serious manifestations.
At the center of the project is the investigation of determinants of the transition from uncomplicated community acquired pneumonia (uCAP) to severe CAP (sCAP) which leads to septic shock (ssCAP).
Goal: Molecular predictors for individual disease courses - new biomarkers, derived from GTP
Surviving severe pneumonia depends not only on pathogens, the pathogen
resistance situation or existing comorbidities and environmental
influences but also on genetic factors which decisively determine a
patient’s immune status.
PROGRESS combines well defined clinical phenotypes with DNA, RNA and proteins which are obtained, with the aid of high throughoutput experimentation, from peripheral blood. In this way, fundamental genetic and molecular disease characteristics can be brought into relation with clinical aspects of the infection, and as a result, typical signatures (“fingerprints”) identification is made possible.
Cross-section comparisons of such signatures in patients with and without disease progression serve to develop risk-factor models for the forecasting of severe disease progression. Furthermore, analyses of changes in molecular markers within disease progressions and the various forms of pneumonia should facilitate better understanding of the fundamental pathophysiological processes. This approach should contribute to the creation of diagnostic tools and thus optimize the care of patients suffering from pneumonia based on improved decision-making.
PROGRESS Coordinator Prof. Dr. Norbert Suttorp
Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie
Charité - Universitätsmedizin Berlin
Augustenburger Platz 1