CAPNETZ Publications

2024

  1. Pappe E, Hübner RH, Saccomanno J, Ebrahimi HDN, Witzenrath M, Wiessner A, Sarbandi K, Xiong Z, Kursawe L, Moter A, Kikhney J. (2024) Biofilm infections of endobronchial valves in COPD patients after endoscopic lung volume reduction: a pilot study with FISHseq. Sci Rep. 14(1):23078. doi: 10.1038/s41598-024-73950-3.
  2. Bahrs C, Schönherr C, Panning M, Rose N, Dähne T, Hagel S, Weis S, Rupp J, Rohde G, Witzenrath M, Pletz MW; CAPNETZ Study Group. (2024) Frequency and clinical significance of Herpes simplex virus type 1/2 reactivation in adult patients with mild to moderately severe community-acquired pneumonia: a multicenter cohort study. Infection In press  doi: 10.1007/s15010-024-02351-5 
  3. Rainer Knoll, Elisa T. Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D. Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, CAPNETZ Study Group, Pa-COVID-19 Study Group, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K. Polansky, Birgit Sawitzki, Leif E. Sander, Joachim L. Schultze, Anna C. Aschenbrenner, Florian Kurth. (2024) The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation. Cell  187(16):4318-4335.e20.  doi:10.1016/j.cell.2024.06.014 
  4. Röwekamp I, Maschirow L, Rabes A, Fiocca Vernengo F, Hamann L, Heinz GA, Mashreghi MF, Caesar S, Milek M, Fagundes Fonseca AC, Wienhold SM, Nouailles G, Yao L, Mousavi S, Bruder D, Boehme JD, Puzianowska-Kuznicka M, Beule D, Witzenrath M; CAPNETZ Study Group; Löhning M, Klose CSN, Heimesaat MM, Diefenbach A, Opitz B. (2024) IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota. Proc Natl Acad Sci USA 121(22):e2310864121.  doi: 10.1073/pnas.2310864121 
  5. Dähne T, Bauer W, Essig A, Schaaf B, Barten- Neiner G, Spinner CD, Pletz MW, Rohde G, Rupp J, Witzenrath M, Panning M; Members of the CAPNETZ study group. (2024) Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)-A prospective multicenter study . J Clin Virol 173:105694.  doi: 10.1016/j.jcv.2024.105694 
  6. Meyer HJ, Mödl L, Unruh O, Xiang W, Berger S, Müller-Plathe M, Rohde G, Pletz MW, Rupp J, Suttorp N, Witzenrath M, Zoller T, Mittermaier M, Steinbeis F; CAPNETZ study group. (2024) Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study. Infection 2024 May 18.  doi: 10.1007/s15010-024-02292-z 
  7. Gheitasi R, Röll D, Müller MM, Naseri M, König R, Slevogt H, Pletz MW, Makarewicz O. (2024) Exploring secretory proteome and cytokine kinetics of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria . Front Immunol . 15:1334616.  doi: 10.3389/fimmu.2024 
  8. Lebedin M, Ratswohl C, Garg A, Schips M, García CV, Spatt L, Thibeault C, Obermayer B, Weiner J, Velásquez IM, Gerhard C, Stubbemann P, Hanitsch LG, Pischon T, Witzenrath M, Sander LE, Kurth F , Meyer-Hermann M, de la Rosa K. (2024) Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses. iScience 27(3):109330.  doi: 10.1016/j.isci.2024.109330 .
  9. Nieuwenhuizen NE, Nouailles G, Sutherland JS, Zyla J, Pasternack AH, Heyckendorf J, Frye BC, Höhne K, Zedler U, Bandermann S, Abu Abed U, Brinkmann V, Gutbier B, Witzenrath M, Suttorp N, Zissel G, Lange C, Ritvos O, Kaufmann SHE; CAPNETZ Study group; DZIF TB study group. (2024) Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection. mBio 15(3):e0340823.  doi: 10.1128/mbio.03408-23
  10. Schleenvoigt, BT, Ankert, J., Barten- Neiner, G., Voit, F., Suttorp, N., Boesecke, C., Hoffmann, C., Stolz, D., Pletz, MW, Rohde, G., Witzenrath, M., Panning, M., Essig, A., Rupp, J., Degen, O., Stephan, C.; CAPNETZ Study Group. (2024) Pathogen spectrum of community-acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ cohort. Infection 52(1):129-137.  doi: 10.1007/s15010-023-02070-3

2023

  1. Enersen CC, Egelund GB, Petersen PT, Andersen S, Ravn P, Rohde G, Lindegaard B, Jensen AV. (2023) The ratio of neutrophil-to-lymphocyte and platelet-to-lymphocyte and association with mortality in community-acquired pneumonia: a derivation-validation cohort study. Infection 51(5):1339-1347. doi: 10.1007/s15010-023-01992-2
  2. Pappe E, Hammerich R, Saccomanno J, Sgarbossa T, Pohrt A, Schmidt B, Grah C, Eisenmann S, Holland A, Eggeling S, Stanzel F, Witzenrath M, Hübner RH. (2023) Impact of Coronavirus Disease 2019 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD. Chronic Obstr Pulm Dis 10(3):211-223. doi: 10.15326/jcopdf.2022.0383 
  3.  Wetzke, M., Schütz, K., Kopp, MV, Seidenberg, J., Vogelberg, C., Ankermann, T., Happle, C., Voigt, G., Köster, H., Illig, T., Lex, C., Schuster, A., Maier, R., Panning, M., Barten, G., Rohde, G., Welte, T., Hansen, G. Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia . ERJ Open Res . 2023 Mar 13;9(2):00286-2022. doi: 10.1183/23120541.00286-2022
  4. Goekeri, C., Pennitz, P., Grönewald, W., Behrendt, U., Kirsten, H., Zobel, CM, Berger, S., Heinz, GA, Mashreghi, MF., Wienhold, SM., Dietert, K., Dorhoi, A., Gruber, AD, Scholz, M., Rohde, G., Suttorp, N., CAPNETZ Study Group, Witzenrath, M., Nouailles, G. (2023). MicroRNA-223 dampens pulmonary inflammation during pneumococcal pneumonia. Cells , 12(6), 959. doi: 10.3390/cells12060959
  5. Chung, HY, Wickel, J., Oswald, M., Dargvainiene, J., Rupp, J., Rohde, G., Witzenrath, M., Leypoldt, F., König, R., Pletz, MW, & Geis , C. (2023). Neurofilament light chain levels predict encephalopathy and outcome in community-acquired pneumonia. Annals of Clinical and Translational Neurology 10(2)204-212. doi: 10.1002/ACN3.51711

2022

  1. Julius, C., Pletz, M.W., Rupp, J., Witzenrath, M., Barten-Neiner, G., & Rohde, G. (2022). Pneumonia in the third year of the pandemic: one eye on the pathogens, the other on the host. American Journal of Physiology. Lung Cellular and Molecular Physiology , 323 (5), L611–L614. doi: 10.1152/AJPLUNG.00330.2022
  2. Bahrs, C., Kesselmeier, M., Kolditz, M., Ewig, S., Rohde, G., Barten-Neiner, G., Rupp, J., Witzenrath, M., Welte, T., Pletz, MW, the CAPNETZ Study Group (2022). A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany . European Respiratory Journal 59(2): 2102432, doi: 10.1183/13993003.02432-2021 .
  3. Sauer, A., Seeliger, B., Jandl, K., Erfinanda, L., Wilhelm, J., Alexopoulos, I., Baal, N., Birnhuber, A., David, S., Welte, T., Barreto, G., Gaertner, U., Kwapiszewska, G., Seeger, W., Kuebler, WM, Schaefer, L., & Wygrecka, M. (2022). Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding . Matrix Biology : Journal of the International Society for Matrix Biology , 114 , 67–83. doi: 10.1016/J.MATBIO.2022.11.003
  4. Wetzke, M., Schütz, K., Kopp, MV, Seidenberg, J., Vogelberg, C., Ankermann, T., Happle, C., Voigt, G., Köster, H., Illig, T., Lex, C., Schuster, A., Maier, R., Panning, M., Barten, G., Rohde, G., Welte, T., & Hansen, G. (2022). Pathogen spectra in hospitalised and non-hospitalised children with community acquired pneumonia . ERJ Open Research , 00286–02022. doi: 10.1183/23120541.00286-2022
  5. Glöckner, V., Pletz, MW, Rohde, G., Rupp, J., Witzenrath, M., Barten-Neiner, G., Kolditz, M., Dreher, M., Cornelissen, C., Knüppel, W., Stolz, D., Suttorp, N., Creutz, P., Witzenrath, M., Mikolajewska, A., le Claire, A., Benzke, M., Bauer, T., Krieger, D., … Wallner, M. (2022). Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool. European Journal of Clinical Microbiology and Infectious Diseases , 41 (4), 621–630. doi: 10.1007/s10096-022-04416-5
  6. Pletz, M.W., Hagel, S., & Weis, S. (2022). In-hospital mortality of patients with severe bloodstream infection: Just the tip of the iceberg. The Lancet Infectious Diseases , 22(5), 576–577. doi: 10.1016/S1473-3099(21)00619-8
  7. Pletz, MW, Jensen, AV, Bahrs, C., Davenport, C., Rupp, J., Witzenrath, M., Barten-Neiner, G., Kolditz, M., Dettmer, S., Chalmers, JD, Stolz, D., Suttorp, N., Aliberti, S., Kuebler, WM, & Rohde, G. (2022). Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group. Respiratory Research , 23 (1), 239. doi: 10.1186/s12931-022-02117-3
  8. Quellhorst, L., Barten-Neiner, G., de Roux, A., Diel, R., Mertsch, P., Pink, I., Rademacher, J., Sutharsan, S., Welte, T., Zurawski, A., & Ringshausen, F. C. (2022). Psychometric validation of the German translation of the Quality of Life Questionnaire – Bronchiectasis (QOL-B): Data from the German bronchiectasis registry PROGNOSIS. Journal of Clinical Medicine , 11 (2). doi: 10.3390/jcm11020441
  9. Rajam, G., Zhang, Y., Antonello, JM, Grant-Klein, RJ, Cook, L., Panemangalore, R., Pham, H., Cooper, S., Steinmetz, TD, Nguyen, J., Pletz , MW, Barten-Neiner, G., Murphy, RD, Rubinstein, LJ, & Nolan, KM (2022). Development and validation of a sensitive and robust multiplex antigen capture assay to quantify Streptococcus pneumoniae serotype-specific capsular polysaccharides in urine. MSphere , 7 (4). doi: 10.1128/msphere.00114-22
  10. Wienhold, SM, Brack, MC, Nouailles, G., Krishnamoorthy, G., Korf, IHE, Seitz, C., Wienecke, S., Dietert, K., Gurtner, C., Kershaw, O., Gruber, AD, Ross, A., Ziehr, H., Rohde, M., Neudecker, J., Lienau, J., Suttorp, N., Hippenstiel, S., Hocke, AC, … Witzenrath, M. (2022). Preclinical assessment of bacteriophage therapy against experimental Acinetobacter baumannii lung infection. Viruses , 14 (1). doi: 10.3390/v14010033
2021
  1. Voigt, G. M., Thiele, D., Wetzke, M., Weidemann, J., Parpatt, P. M., Welte, T., Seidenberg, J., Vogelberg, C., Koster, H., Rohde, G. G. U., Härtel, C., Hansen, G., & Kopp, M. v. (2021). Interobserver agreement in interpretation of chest radiographs for pediatric community acquired pneumonia: Findings of the pedCAPNETZ-cohort. Pediatric Pulmonology, 56(8), 2676–2685. doi: 10.1002/PPUL.25528
  2. Bellinghausen, C., Pletz, M. W., Rupp, J., Witzenrath, M., Welsch, C., Zeuzem, S., Trebicka, J., & Rohde, G. G. U. (2021). Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia. Gut, 70(1), 221–222. doi: 10.1136/gutjnl-2020-320876
  3. Braeken, D. C. W., Essig, A., Panning, M., Hoerster, R., Nawrocki, M., Dalhoff, K., Suttorp, N., Welte, T., Pletz, M. W., Witzenrath, M., Rohde, G. G. U., Rupp, J., Dreher, M., Cornelissen, C., Knüppel, W., Stolz, D., Bauer, W., Mikolajewska, A., Pankow, W., … Traby, L. (2021). Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade. Infection, 49(3), 533–537. doi: 10.1007/s15010-021-01605-w
  4. Dähne, T., Bauer, W., Essig, A., Schaaf, B., Spinner, C. D., Pletz, M. W., Rohde, G., Rupp, J., Witzenrath, M., & Panning, M. (2021). The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany. In Emerging Microbes and Infections, 10(1), 1515–1518. doi: 10.1080/22221751.2021.1957402
  5. Ehrlich, K., Wilhelm, J., Markart, P., Weisser, H., Wolff, J. C., Bein, G., Pak, O., Barreto, G., Weissmann, N., Schramm, F., Seeger, W., Schaefer, L., Kuebler, W. M., & Wygrecka, M. (2021). Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia. American Journal of Physiology – Lung Cellular and Molecular Physiology, 321(4), L764–L774. doi: 10.1152/ajplung.00162.2021
  6. Ewig, S., Kolditz, M., Pletz, M., Altiner, A., Albrich, W., Drömann, D., Flick, H., Gatermann, S., Krüger, S., Nehls, W., Panning, M., Rademacher, J., Rohde, G., Rupp, J., Schaaf, B., Heppner, H. J., Krause, R., Ott, S., Welte, T., & Witzenrath, M. (2021). Behandlung von erwachsenen Patienten mit ambulant erworbener Pneumonie – Update 2021. Pneumologie, 75(9), 665–729. doi: 10.1055/a-1497-0693
  7. Rothe, K., Spinner, C. D., Panning, M., Pletz, M. W., Rohde, G., Rupp, J., Witzenrath, M., Erber, J., Eberhardt, F., Essig, A., Schneider, J., Dreher, M., Cornelissen, C., Knüppel, W., Stolz, D., Suttorp, N., Creutz, P., Mikolajewska, A., le Claire, A., … Wallner, M. (2021). Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ). Infection, 49(6), 1299–1306. doi: 10.1007/s15010-021-01720-8
2020
  1. Forstner, C., Kolditz, M., Kesselmeier, M., Ewig, S., Rohde, G., Barten-Neiner, G., Rupp, J., Witzenrath, M., Welte, T., & Pletz, M. W. (2020). Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia. Vaccine, 38(5), 1129–1136. doi: 10.1016/j.vaccine.2019.11.026
  2. Forstner, C., Patchev, V., Rohde, G., Rupp, J., Witzenrath, M., Welte, T., Burgmann, H., Pletz, M. W., Dreher, M., Cornelissen, C., Knüppel, W., Stolz, D., Suttorp, N., Witzenrath, M., Creutz, P., Mikolajewska, A., Bauer, T., Krieger, D., Pankow, W., … Wallner, M. (2020). Rate and predictors of bacteremia in afebrile community-acquired pneumonia. Chest, 157(3), 529–539. doi: 10.1016/j.chest.2019.10.006
  3. Panning, M., Wiener, J., Rothe, K., Schneider, J., Pletz, M. W., Rohde, G., Rupp, J., Witzenrath, M., Spinner, C. D., Dreher, M., Cornelissen, C., Knüppel, W., Stolz, D., Suttorp, N., Bauer, W., Mikolajewska, A., Pankow, W., Gläser, S., Thiemig, D., … Traby, L. (2020). No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020. Infection, 48(6), 971–974. doi: 10.1007/s15010-020-01471-y

2019

  1. Wetzke, M., Kopp, M. V., Seidenberg, J., Vogelberg, C., Ankermann, T., Happle, C., Voigt, G., Köster, H., Illig, T., Lex, C., Schuster, A., Panning, M., Barten, G., Rohde, G., Welte, T., & Hansen, G. (2019). PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents. BMC Pulmonary Medicine, 19(1). doi: 10.1186/S12890-019-1013-5
  2. Bonnesen, B., Baunbæk Egelund, G., Vestergaard Jensen, A., Andersen, S., Trier Petersen, P., Rohde, G., & Ravn, P. (2019). Is chronic obstructive pulmonary disease a risk factor for death in patients with community acquired pneumonia? Infectious Diseases, 51(5), 340–347. doi: 10.1080/23744235.2019.1565416
  3. Deinhardt-Emmer, S., Haupt, K. F., Garcia-Moreno, M., Geraci, J., Forstner, C., Pletz, M., Ehrhardt, C., & Löffer, B. (2019). Staphylococcus aureus pneumonia: Preceding influenza infection paves the way for low-virulent strains. Toxins, 11(12). doi: 10.3390/toxins11120734
  4. Jensen, A. V., Baunbæk Egelund, G., Bang Andersen, S., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., & Faurholt-Jepsen, D. (2019). The glycemic gap and 90-Day mortality in community-acquired pneumonia. A prospective cohort study. Annals of the American Thoracic Society, 16(12), 1518–1526. doi: 10.1513/AnnalsATS.201901-007OC
  5. König, R., Cao, X., Oswald, M., Forstner, C., Rohde, G., Rupp, J., Witzenrath, M., Welte, T., Kolditz, M., & Pletz, M. (2019). Macrolide combination therapy for patients hospitalised with community-acquired pneumonia? An individualised approach supported by machine learning. European Respiratory Journal, 54(6). doi: 10.1183/13993003.00824-2019
  6. Schöll, N., & Rohde, G. G. U. (2019). Community-acquired pneumonia in the elderly. Pneumologie, 73(10), 605–616. doi: 10.1055/a-0835-1943
  7. Wetzke, M., Kopp, M. V., Seidenberg, J., Vogelberg, C., Ankermann, T., Happle, C., Voigt, G., Köster, H., Illig, T., Lex, C., Schuster, A., Panning, M., Barten, G., Rohde, G., Welte, T., & Hansen, G. (2019). PedCAPNETZ – Prospective observational study on community acquired pneumonia in children and adolescents. BMC Pulmonary Medicine, 19(1). doi: 10.1186/s12890-019-1013-5

2018

  1. Gutbier, B., Neuhauß, A. K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., & Witzenrath, M. (2018). Prognostic and pathogenic role of angiopoietin-1 and -2 in pneumonia. American Journal of Respiratory and Critical Care Medicine, 198(2), 220–231. doi: 10.1164/rccm.201708-1733OC
  2. Gutbier, B., Schönrock, S. M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A. D., Kummer, W., Michalick, L., Kuebler, W. M., Hocke, A. C., Szymanski, K., Letsiou, E., Lüth, A., Schumacher, F., Kleuser, B., Mitchell, T. J., Bertrams, W., Schmeck, B., Treue, D., … Wallner, M. (2018). Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the sphingosine-1-phosphate receptor 2. Critical Care Medicine, 46(3), E258–E267. doi: 10.1097/CCM.0000000000002916
  3. Petersen, P. T., Egelund, G. B., Jensen, A. V., Andersen, S. B., Pedersen, M. F., Rohde, G., & Ravn, P. (2018). Associations between biomarkers at discharge and co-morbidities and risk of readmission after community-acquired pneumonia: a retrospective cohort study. European Journal of Clinical Microbiology and Infectious Diseases, 37(6), 1103–1111. doi: 10.1007/s10096-018-3224-8
  4. Ruiz-Moreno, J. S., Hamann, L., Jin, L., Sander, L. E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R. R., Suttorp, N., & Opitz, B. (2018). The cGAS/STING pathway detects Streptococcus pneumoniae but appears dispensable for antipneumococcal defense in mice and humans. Infection and Immunity, 86(3). doi: 10.1128/IAI.00849-17
  5. Ruiz-Moreno, J. S., Hamann, L., Shah, J. A., Verbon, A., Mockenhaupt, F. P., Puzianowska-Kuznicka, M., Naujoks, J., Sander, L. E., Witzenrath, M., Cambier, J. C., Suttorp, N., Schumann, R. R., Jin, L., Hawn, T. R., & Opitz, B. (2018). The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans. PLoS Pathogens, 14(1). doi: 10.1371/journal.ppat.1006829

2017

  1. Andersen, S. B., Baunbæk Egelund, G., Jensen, A. V., Petersen, P. T., Rohde, G., & Ravn, P. (2017). Failure of CRP decline within three days of hospitalization is associated with poor prognosis of community-acquired pneumonia. Infectious Diseases, 49(4), 251–260. doi: 10.1080/23744235.2016.1253860
  2. Braeken, D. C. W., Franssen, F. M. E., von Baum, H., Schütte, H., Pletz, M. W., Rupp, J., Stassen, F., Mooij, M. J., & Rohde, G. G. U. (2017). Bacterial aetiology and mortality in COPD patients with CAP: Results from the German Competence Network, CAPNETZ. International Journal of Tuberculosis and Lung Disease, 21(2), 236–243. doi: 10.5588/ijtld.16.0567
  3. Egelund, G. B., Jensen, A. V., Andersen, S. B., Petersen, P. T., Lindhardt, B. Ø., von Plessen, C., Rohde, G., & Ravn, P. (2017). Penicillin treatment for patients with community-acquired pneumonia in Denmark: A retrospective cohort study. BMC Pulmonary Medicine, 17(1). doi: 10.1186/s12890-017-0404-8
  4. Jensen, A. V., Egelund, G. B., Andersen, S. B., Petersen, P. T., Benfield, T., Faurholt-Jepsen, D., Rohde, G., & Ravn, P. (2017). The impact of blood glucose on community-acquired pneumonia: A retrospective cohort study. ERJ Open Research, 3(2). doi: 10.1183/23120541.00114-2016
  5. Jensen, A. V., Faurholt-Jepsen, D., Egelund, G. B., Andersen, S. B., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., & Ravn, P. (2017). Undiagnosed diabetes mellitus in community-acquired pneumonia: A prospective cohort study. Clinical Infectious Diseases, 65(12), 2091–2098. doi: 10.1093/cid/cix703

2016

  1. Forstner, C., Rohde, G., Rupp, J., Schuette, H., Ott, S. R., Hagel, S., Harrison, N., Thalhammer, F., von Baum, H., Suttorp, N., Welte, T., Pletz, M. W., Krüger, S., Frechen, D., Knüppel, W., Armari, I., Stolz, D., Suttorp, N., Schütte, H., … Rainer, G. (2016). Community-acquired Haemophilus influenzae pneumonia – New insights from the CAPNETZ study. Journal of Infection, 72(5), 554–563. doi: 10.1016/j.jinf.2016.02.010
  2. Kolditz, M., Scherag, A., Rohde, G., Ewig, S., Welte, T., Pletz, M., & on behalf of the CAPNETZ Study Group. (2016). Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intensive Care Medicine, 42(12), 2108–2110. doi: 10.1007/s00134-016-4517-y
  3. Pletz, M. W., Ewig, S., Rohde, G., Schuette, H., Rupp, J., Welte, T., Suttorp, N., Forstner, C., Krüger, S., Frechen, D., Knüppel, W., Armari, I., Stolz, D., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Hecht, J., Pankow, W., … Rainer, G. (2016). Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay. Vaccine, 34(20), 2342–2348. doi: 10.1016/j.vaccine.2016.03.052
  4. Suttorp, N., Welte, T., Marre, R., Stenger, S., Pletz, M., Rupp, J., Schütte, H., & Rohde, G. (2016). CAPNETZ: The competence network for community-acquired pneumonia (CAP). Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 59(4), 475–481. doi: 10.1007/s00103-016-2318-7

2015

  1. Dumke, R., Schnee, C., Pletz, M. W., Rupp, J., Jacobs, E., Sachse, K., Rohde, G., Dreher, M., Cornelissen, C., Knüppel, W., Armari, I., Stolz, D., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Weiß, T., Pankow, W., Lies, A., … Wallner, M. (2015). Mycoplasma pneumoniae and Chlamydia spp. infection in community-acquired pneumonia, Germany, 2011–2012. Emerging Infectious Diseases, 21(3), 426–434. doi: 10.3201/eid2103.140927
  2. Kolditz, M., Ewig, S., Klapdor, B., Schütte, H., Winning, J., Rupp, J., Suttorp, N., Welte, T., Rohde, G., Dreher, M., Cornelissen, C., Knüppel, W., Amari, I., Stolz, D., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Weiß, T., … Wallner, M. (2015). Community-acquired pneumonia as medical emergency: Predictors of early deterioration. Thorax, 70(6), 551–558. doi: 10.1136/thoraxjnl-2014-206744
  3. Kolditz, M., Ewig, S., Schütte, H., Suttorp, N., Welte, T., & Rohde, G. (2015). Assessment of oxygenation and comorbidities improves outcome prediction in patients with community-acquired pneumonia with a low CRB-65 score. Journal of Internal Medicine, 278(2), 193–202. doi: 10.1111/joim.12349
2014
  1. Bierbaum, S., Forster, J., Berner, R., Rücker, G., Rohde, G., Neumann-Haefelin, D., & Panning, M. (2014). Detection of respiratory viruses using a multiplex real-time PCR assay in Germany, 2009/10. Archives of Virology, 159(4), 669–676. doi: 10.1007/s00705-013-1876-3
  2. Krüger, S., Ewig, S., Giersdorf, S., Hartmann, O., Frechen, D., Rohde, G., Suttorp, N., & Welte, T. (2014). Dysnatremia, vasopressin, atrial natriuretic peptide and mortality in patients with community-acquired pneumonia: Results from the German competence network CAPNETZ. Respiratory Medicine, 108(11), 1696–1705. doi: 10.1016/j.rmed.2014.09.014
  3. Majcher-Peszynska, J., Loebermann, M., Klammt, S., Frimmel, S., Mundkowski, R. G., Welte, T., Reisinger, E. C., Drewelow, B., Krüger, S., Frechen, D., Knüppel, W., Armari, I., Stolz, D., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Hecht, J., Pankow, W., … Rainer, G. (2014). Ampicillin/sulbactam in elderly patients with community-acquired pneumonia. Infection, 42(1), 79–87. doi: 10.1007/s15010-013-0518-8
  4. Pletz, M. W., Terkamp, C., Schumacher, U., Rohde, G., Schütte, H., Welte, T., Bals, R., Krüger, S., Frechen, D., Knüppel, W., Armari, I., Suttorp, N., Schütte, H., Creutz, P., Bauer, T., Hecht, J., Pankow, W., Lies, A., Thiemig, D., … Stolz, D. (2014). Vitamin D deficiency in community-acquired pneumonia: Low levels of 1,25(OH)2 D are associated with disease severity. Respiratory Research, 15(1). doi: 10.1186/1465-9921-15-53
  5. Schack, M., Sachse, S., Rödel, J., Frangoulidis, D., Pletz, M. W., Rohde, G. U., Straube, E., & Boden, K. (2014). Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. Epidemiology and Infection, 142(9), 1905–1910. doi: 10.1017/S0950268813002914

2013

  1. Pletz, M. W., Michaylov, N., Schumacher, U., van der Linden, M., Duesberg, C. B., Fuehner, T., Klugman, K. P., Welte, T., & Makarewicz, O. (2013). Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: An in vitro study. International Journal of Medical Microbiology, 303(4), 176–181. doi: 10.1016/j.ijmm.2013.02.014

2012

  1. Ewig, S., Klapdor, B., Pletz, M. W., Rohde, G., Schütte, H., Schaberg, T., Bauer, T. T., & Welte, T. (2012). Nursing-home-acquired pneumonia in Germany: An 8-year prospective multicentre study. Thorax, 67(2), 132–138. doi: 10.1136/thoraxjnl-2011-200630
  2. Klapdor, B., Ewig, S., Pletz, M. W., Rohde, G., Schütte, H., Schaberg, T., & Weltee, T. (2012). Community-acquired pneumonia in younger patients is an entity on its own. European Respiratory Journal, 39(5), 1156–1161. doi: 10.1183/09031936.00110911
  3. Klapdor, B., Ewig, S., Schaberg, T., Rohde, G., Pletz, M. W., Schütte, H., Welte, T., Kreuger, S., Stolz, D., Suttorp, N., Scheutte, H., Tessmer, A., Martus, P., Bauer, T., Hecht, J., Pankow, W., Lies, A., Thiemig, D., Hauptmeier, B., … Rainer, G. (2012). Presentation, etiology and outcome of pneumonia in younger nursing home residents. Journal of Infection, 65(1), 32–38. doi: 10.1016/j.jinf.2012.02.003
  4. Kolditz, M., Höffken, G., Martus, P., Rohde, G., Schütte, H., Bals, R., Suttorp, N., & Pletz, M. W. (2012). Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: A prospective observational cohort study. BMC Infectious Diseases, 12. doi: 10.1186/1471-2334-12-90
  5. Lepper, P. M., Ott, S., Nüesch, E., von Eynatten, M., Schumann, C., Pletz, M. W., Mealing, N. M., Welte, T., Bauer, T. T., Suttorp, N., Jüni, P., Bals, R., & Rohde, G. (2012). Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: Prospective cohort study. BMJ (Online), 344(7861). doi: 10.1136/bmj.e3397
  6. Pletz, M. W., von Baum, H., van der Linden, M., Rohde, G., Schütte, H., Suttorp, N., & Welte, T. (2012). The burden of pneumococcal pneumonia – Experience of the German competence network CAPNETZ. Pneumologie, 66(8), 470–475. doi: 10.1055/s-0032-1310103
  7. Zobel, K., Martus, P., Pletz, M. W., Ewig, S., Prediger, M., Welte, T., & Bühling, F. (2012). Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: Results from the German competence network CAPNETZ. BMC Pulmonary Medicine, 12. doi: 10.1186/1471-2466-12-6

2011

  1. Ewig, S., Hecker, H., Suttorp, N., Marre, R., & Welte, T. (2011). Moxifloxacin monotherapy versus ß-lactam mono- or combination therapy in hospitalized patients with community-acquired pneumonia. Journal of Infection, 62(3), 218–225. doi: 10.1016/j.jinf.2011.01.009
  2. Pletz, M. W., van der Linden, M., von Baum, H., Duesberg, C. B., Klugman, K. P., & Welte, T. (2011). Low prevalence of fluoroquinolone resistant strains and resistance precursor strains in Streptococcus pneumoniae from patients with community-acquired pneumonia despite high fluoroquinolone usage. International Journal of Medical Microbiology, 301(1), 53–57. doi: 10.1016/j.ijmm.2010.05.004
  3. Rudolf, D., Michaylov, N., van der Linden, M., Hoy, L., Klugman, K. P., Welte, T., & Pletz, M. W. (2011). International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance. Antimicrobial Agents and Chemotherapy, 55(10), 4915–4917. doi: 10.1128/AAC.00250-11
  4. Tessmer, A., Welte, T., Schmidt-Ott, R., Eberle, S., Barten, G., Suttorp, N., & Schaberg, T. (2011). Influenza vaccination is associated with reduced severity of community-acquired pneumonia. European Respiratory Journal, 38(1), 147–153. doi: 10.1183/09031936.00133510
  5. von Baum, H., Schweiger, B., Welte, T., Marre, R., Suttorp, N., Pletz, M. W. R., Ewige, S., Rohde, G., Hauptmeier, B., Schaberg, T., Hering, I., Dalhoff, K., Heyer, P., Schumann, C., Bauer, T., Kunitz, F., Schütte, H., Tessmer, A., Rademacher, J., … Gosman, L. (2011). How deadly is seasonal influenza-associated pneumonia? The German Competence Network for Community-Acquired Pneumonia. European Respiratory Journal, 37(5), 1151–1157. doi: 10.1183/09031936.00037410

2010

  1. Dumke, R., von Baum, H., Lück, P. C., & Jacobs, E. (2010a). Occurrence of macrolide-resistant Mycoplasma pneumoniae strains in Germany. Clinical Microbiology and Infection, 16(6), 613–616. doi: 10.1111/j.1469-0691.2009.02968.x
  2. Dumke, R., von Baum, H., Lück, P. C., & Jacobs, E. (2010b). Subtypes and variants of Mycoplasma pneumoniae: Local and temporal changes in Germany 2003-2006 and absence of a correlation between the genotype in the respiratory tract and the occurrence of genotype-specific antibodies in the sera of infected patients. Epidemiology and Infection, 138(12), 1829–1837. doi: 10.1017/S0950268810000622
  3. Krüger, S., Ewig, S., Giersdorf, S., Hartmann, O., Suttorp, N., Welte, T., Becker, M., Kuhnke, A., Lode, H., Schmidt-Ioanas, M., Bauer, T., Schlosser, B., Pletz, M., Dalhoff, K., Pischke, S., Schübel, N., Huntemann, I., Lorenz, J., Klante, T., … Gosmann, L. (2010). Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ. American Journal of Respiratory and Critical Care Medicine, 182(11), 1426–1434. doi: 10.1164/rccm.201003-0415OC
  4. Krüger, S., Ewig, S., Kunde, J., Hartmann, O., Marre, R., Suttorp, N., & Welte, T. (2010). Assessment of inflammatory markers in patients with community-acquired pneumonia – Influence of antimicrobial pre-treatment. Results from the German competence network CAPNETZ. Clinica Chimica Acta, 411(23–24), 1929–1934. doi: 10.1016/j.cca.2010.08.004
  5. Krüger, S., Ewig, S., Kunde, J., Hartmann, O., Suttorp, N., & Welte, T. (2010). Pro-atrial natriuretic peptide and pro-vasopressin for predicting short-term and long-term survival in community-acquired pneumonia: Results from the German competence network CAPNETZ. Thorax, 65(3), 208–214. doi: 10.1136/thx.2009.121178
  6. Schnoor, M., Meyer, T., Suttorp, N., Raspe, H., Welte, T., & Schäfer, T. (2010). Development and evaluation of an implementation strategy for the German guideline on community-acquired pneumonia. Quality and Safety in Health Care, 19(6), 498–502. doi: 10.1136/qshc.2008.029629
  7. von Baum, H., Welte, T., Marre, R., Suttorp, N., & Ewig, S. (2010a). Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: Diagnosis, incidence and predictors. European Respiratory Journal, 35(3), 598–605. doi: 10.1183/09031936.00091809

2009

  1. Herr, C., Beisswenger, C., Hess, C., Kandler, K., Suttorp, N., Welte, T., Schroeder, J. M., Vogelmeier, C., & Bals, R. (2009). Suppression of pulmonary innate host defence in smokers. Thorax, 64(2), 144–149. doi: 10.1136/thx.2008.102681
  2. Krüger, S., Ewig, S., Kunde, J., Hanschmann, A., Marre, R., Suttorp, N., Welte, T., Becker, M., Kuhnke, A., Lode, H., Schmidt-Ioanas, M., Suttorp, B., Bauer, T., Ewig, S., Schlosser, B., Plets, M., Dalhoff, K., Pischke, S., Schübel, N., … Richter, K. (2009). C-terminal provasopressin (copeptin) in patients with community-acquired pneumonia – Influence of antibiotic pre-treatment: Results from the German competence network CAPNETZ. Journal of Antimicrobial Chemotherapy, 64(1), 159–162. doi: 10.1093/jac/dkp148
  3. Krüger, S., Ewig, S., Papassotiriou, J., Kunde, J., Marre, R., von Baum, H., Suttor, N., & Welte, T. (2009). Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP – Results from the German competence network CAPNETZ. Respiratory Research, 10(1). doi: 10.1186/1465-9921-10-65
  4. Schnoor, M., Schoefer, Y., Henrich, G., Raspe, H., & Schaefer, T. (2009). General and health-related life satisfaction of patients with community-acquired pneumonia. Psychology, Health and Medicine, 14(3), 331–342. doi: 10.1080/13548500802657669
  5. Tessmer, A., Welte, T., Martus, P., Schnoor, M., Marre, R., & Suttorp, N. (2009). Impact of intravenous β-lactam/macrolide versus β-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia. Journal of Antimicrobial Chemotherapy, 63(5), 1025–1033. doi: 10.1093/jac/dkp088
  6. von Baum, H., Welte, T., Marre, R., Suttorp, N., Lück, C., & Ewig, S. (2009). Mycoplasma pneumoniae pneumonia revisited within the German Competence Network for Community-Acquired Pneumonia (CAPNETZ). BMC Infectious Diseases, 9. doi:10.1186/1471-2334-9-62
  7. Welte, T., & Köhnlein, T. (2009). Global and local epidemiology of community-acquired pneumonia: The experience of the CAPNETZ Network. Seminars in Respiratory and Critical Care Medicine, 30(2), 127–135. doi: 10.1055/s-0029-1202941
  8. Witzenrath, M., Gutbier, B., Schmeck, B., Tenor, H., Seybold, J., Kuelzer, R., Grentzmann, G., Hatzelmann, A., van Laak, V., Tschernig, T., Mitchell, T. J., Schudt, C., Rosseau, S., Suttorp, N., & Schütte, H. (2009). Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Critical Care Medicine, 37(2), 584–590. doi: 10.1097/CCM.0b013e3181959814
  9. Witzenrath, M., Schmeck, B., Doehn, J. M., Tschernig, T., Zahlten, J., Loeffler, J. M., Zemlin, M., Müller, H., Gutbier, B., Schütte, H., Hippenstiel, S., Fischetti, V. A., Suttorp, N., & Rosseau, S. (2009). Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Critical Care Medicine, 37(2), 642–649. doi: 10.1097/CCM.0b013e31819586a6

2008

  1. Beisswenger, C., & Bals, R. (2008). Interaction of allergic airway inflammation and innate immunity: Hygiene and beyond. Journal of Occupational Medicine and Toxicology, 3(SUPPL. 1). doi: 10.1186/1745-6673-3-S1-S3
  2. Borchardt, J., Helbig, J. H., & Lück, P. C. (2008). Occurrence and distribution of sequence types among Legionella pneumophila strains isolated from patients in Germany: Common features and differences to other regions of the world. European Journal of Clinical Microbiology and Infectious Diseases, 27(1), 29–36. doi: 10.1007/s10096-007-0392-3
  3. Cabanski, M., Steinmüller, M., Marsh, L. M., Surdziel, E., Seeger, W., & Lohmeyer, J. (2008). PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology, 38(1), 26–31. doi: 10.1165/rcmb.2007-0010OC
  4. Galka, F., Sun, N. W., Kusch, H., Engelmann, S., Hecker, M., Schmeck, B., Hippenstiel, S., Uhlin, B. E., & Steinert, M. (2008). Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles. Infection and Immunity, 76(5), 1825–1836.doi: 10.1128/IAI.01396-07
  5. Hocke, A. C., Hartmann, I. K., Eitel, J., Optiz, B., Scharf, S., Suttorp, N., & Hippenstiel, S. (2008). Subcellular expression pattern and role of IL-15 in pneumococci induced lung epithelial apoptosis. Histochemistry and Cell Biology, 130(1), 165–176. doi: 10.1007/s00418-008-0414-y
  6. Kothe, H., Bauer, T., Marre, R., Suttorp, N., Welte, T., Dalhoff, K., Lode, H., Schmidt-Ioanas, M., Kuhnke, A., Becker, M., Schlosser, B., Marchel, E., Pletz, M., Beiring, C., Schuebel, N., Lorenz, J., Huntemann, I., Klante, T., Schaberg, T., … Schweiger, B. (2008). Outcome of community-acquired pneumonia: Influence of age, residence status and antimicrobial treatment. European Respiratory Journal, 32(1), 139–146. doi: 10.1183/09031936.00092507
  7. Krüger, S., Ewig, S., Marre, R., Papassotiriou, J., Richter, K., von Baum, H., Suttorp, N., & Welte, T. (2008). Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. European Respiratory Journal, 31(2), 349–355. doi: 10.1183/09031936.00054507
  8. Schmeck, B., Beermann, W., Dje N’Guessan, P., Hocke, A. C., Opitz, B., Eitel, J., Dinh, Q. T., Witzenrath, M., Krüll, M., Suttorp, N., & Hippenstiel, S. (2008). Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells. Circulation Research, 102(8), 888–895. doi: 10.1161/CIRCRESAHA.107.161307
  9. Schmeck, B., Lorenz, J., N′Guessan, P. D., Opitz, B., van Laak, V., Zahlten, J., Slevogt, H., Witzenrath, M., Flieger, A., Suttorp, N., & Hippenstiel, S. (2008). Histone acetylation and flagellin are essential for Legionella pneumophila -induced cytokine expression. The Journal of Immunology, 181(2), 940–947. doi: 10.4049/jimmunol.181.2.940
  10. von Baum, H., Ewig, S., Marre, R., Suttorp, N., Gonschior, S., Welte, T., & Lück, C. (2008). Community-acquired Legionella pneumonia: New insights from the German competence network for community acquired pneumonia. Clinical Infectious Diseases, 46(9), 1356–1364. doi: 10.1086/586741

2007

  1. Dumke, R., Schurwanz, N., Lenz, M., Schuppler, M., Lück, C., & Jacobs, E. (2007). Sensitive detection of Mycoplasma pneumoniae in human respiratory tract samples by optimized real-time PCR approach. Journal of Clinical Microbiology, 45(8), 2726–2730. doi: 10.1128/JCM.00321-07
  2. Hammerschmidt, S., Agarwal, V., Kunert, A., Haelbich, S., Skerka, C., & Zipfel, P. F. (2007). The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells. The Journal of Immunology, 178(9), 5848–5858.doi: 10.4049/jimmunol.178.9.5848
  3. Hippenstiel, S., Witzenrath, M., Opitz, B., Schütte, H., Rosseau, S., & Suttorp, N. (2007). Neues zur Pathophysiologie der Pneumonie. Internist, 48(5), 459–467. doi: 10.1007/s00108-007-1837-6
  4. Hocke, A. C., Lampe, M. P., Witzenrath, M., Mollenkopf, H., Zerrahn, J., Schmeck, B., Kessler, U., Krüll, M., Hammerschmidt, S., Hippenstiel, S., Schütte, H., Suttorp, N., & Rosseau, S. (2007). Cell-specific Interleukin-15 and Interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia – comparison to chlamydial lung infection. Cytokine, 38(2), 61–73.doi: 10.1016/j.cyto.2007.05.009
  5. Kohlhammer, Y., Raspe, H., Marre, R., Suttorp, N., Welte, T., & Schäfer, T. (2007). Antibiotic treatment of community acquired pneumonia varies widely across Germany. Journal of Infection, 54(5), 446–453. doi: 10.1016/j.jinf.2006.08.010
  6. Krüger, S., Papassotiriou, J., Marre, R., Richter, K., Schumann, C., von Baum, H., Morgenthaler, N. G., Suttorp, N., Welte, T., Becker, M., Kuhnke, A., Lode, H., Schmidt-Ioanas, M., Bauer, T., Ewig, S., Schlosser, B., Pletz, M., Dalhoff, K., Pischke, S., … Gonschior, S. (2007). Pro-atrial natriuretic peptide and pro-vasopressin to predict severity and prognosis in community-acquired pneumonia: Results from the German competence network CAPNETZ. Intensive Care Medicine, 33(12), 2069–2078. doi: 10.1007/s00134-007-0895-5
  7. Lück, P. C., Ecker, C., Reischl, U., Linde, H. J., & Stempka, R. (2007). Culture-independent identification of the source of an infection by direct amplification and sequencing of Legionella pneumophila DNA from a clinical specimen. Journal of Clinical Microbiology, 45(9(), 3143–3144. doi: 10.1128/JCM.00685-07
  8. N’Guessan, P. D., Etouem, M. O., Schmeck, B., Hocke, A. C., Scharf, S., Vardarova, K., Opitz, B., Flieger, A., Suttorp, N., & Hippenstiel, S. (2007). Legionella pneumophila-induced PKCα-, MAPK-, and NF-κB- dependent COX-2 expression in human lung epithelium. American Journal of Physiology – Lung Cellular and Molecular Physiology, 292(1). doi: 10.1152/ajplung.00100.2006
  9. Opitz, B., Rejaibi, A., Dauber, B., Eckhard, J., Vinzing, M., Schmeck, B., Hippenstiel, S., Suttorp, N., & Wolff, T. (2007). IFNβ induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cellular Microbiology, 9(4), 930–938. doi: 10.1111/j.1462-5822.2006.00841.x
  10. Pauls, S., Krüger, S., Richter, K., Muche, R., Marre, R., Welte, T., Billich, C., Gonschior, S., Schumann, C., Boll, D., Aschoff, A. J., & Suttorp, N. (2007). Detektion pneumonischer Infiltrate bei ambulant erworbener Pneumonie: Übereinstimmung in der Befundung der Röntgen-Thoraxaufnahme. RoFo Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren, 179(11), 1152–1158. doi: 10.1055/s-2007-963286
  11. Ratzow, S., Gaia, V., Helbig, J. H., Fry, N. K., & Lück, P. C. (2007). Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains. Journal of Clinical Microbiology, 45(6), 1965–1968. doi: 10.1128/JCM.00261-07
  12. Rosseau, S., Hocke, A., Mollenkopf, H., Schmeck, B., Suttorp, N., Kaufmann, S. H. E., & Zerrahn, J. (2007). Comparative transcriptional profiling of the lung reveals shared and distinct features of Streptococcus pneumoniae and influenza A virus infection. Immunology, 120(3), 380–391. doi: 10.1111/j.1365-2567.2006.02514.x
  13. Schmeck, B., N’Guessan, P. D., Ollomang, M., Lorenz, J., Zahlten, J., Opitz, B., Flieger, A., Suttorp, N., & Hippenstiel, S. (2007). Legionella pneumonia-induced NF-κB- and MAPK-dependent cytokine release by lung epithelial cells. European Respiratory Journal, 29(1), 25–33. doi: 10.1183/09031936.00141005
  14. Schnoor, M., Hedicke, J., Dalhoff, K., Raspe, H., & Schäfer, T. (2007). Approaches to estimate the population-based incidence of community acquired pneumonia. Journal of Infection, 55(3), 233–239. doi: 10.1016/j.jinf.2007.04.355
  15. Suttorp, N. (Norbert), Welte, T. (Tobias), & Marre, Reinhard. (2007). Community-acquired pneumonia. Birkhäuser Verlag.
2006
  1. Lück, P. C., Helbig, J. H., von Baum, H., & Marre, R. (2014). Diagnostics and clinical disease treatment: Usefulness of microbiological diagnostic methods for detection of Legionella infections. Legionella (pp. 15–21). doi: 10.1128/9781555815660.ch03
  2. Bauer, T. (2006). CAPNETZ: Das Kompetenznetzwerk der ambulant erworbenen Pneumonie in Deutschland. Pneumologie, 60(2), 111–113). doi: 10.1055/s-2005-919157
  3. Bauer, T. T., Ewig, S., Marre, R., Suttorp, N., & Welte, T. (2006). CRB-65 predicts death from community-acquired pneumonia. Journal of Internal Medicine, 260(1), 93–101. doi: 10.1111/j.1365-2796.2006.01657.x
  4. Beisswenger, C., Kandler, K., Hess, C., Garn, H., Felgentreff, K., Wegmann, M., Renz, H., Vogelmeier, C., & Bals, R. (2006). Allergic airway inflammation inhibits pulmonary antibacterial host defense. The Journal of Immunology, 177(3), 1833–1837. doi: 10.4049/jimmunol.177.3.1833
  5. Bergmann, S., & Hammerschmidt, S. (2006). Versatility of pneumococcal surface proteins. Microbiology, 152(2), 295–303.doi: 10.1099/mic.0.28610-0
  6. Dumke, R., Lück, P. C., Noppen, C., Schaefer, C., von Baum, H., Marre, R., & Jacobs, E. (2006). Culture-independent molecular subtyping of Mycoplasma pneumoniae in clinical samples. Journal of Clinical Microbiology, 44(7), 2567–2570. doi: 10.1128/JCM.00495-06
  7. Felgentreff, K., Beisswenger, C., Griese, M., Gulder, T., Bringmann, G., & Bals, R. (2006). The antimicrobial peptide cathelicidin interacts with airway mucus. Peptides, 27(12), 3100–3106. doi: 10.1016/j.peptides.2006.07.018
  8. Hamann, L., Glaeser, C., Hamprecht, A., Gross, M., Gomma, A., & Schumann, R. R. (2006). Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clinica Chimica Acta, 364(1–2), 303–307. doi: 10.1016/j.cca.2005.07.017
  9. Hammerschmidt, S. (2006). Adherence molecules of pathogenic pneumococci. Current Opinion in Microbiology, 9(1), 12–20. doi: 10.1016/j.mib.2005.11.001
  10. Hedicke, J., Schnoor, M., Schübel, N., Gadji, D., Dalhoff, K., Raspe, H., & Schäfer, T. (2006). Ergebnisvergleich: Aktives versus passives Meldesystem bei Fällen mit ambulant erworbener Pneumonie: Ergebnisse aus dem Kompetenznetzwerk CAPNETZ. Gesundheitswesen, 68(10), 638–642. doi: 10.1055/s-2006-927048
  11. Hermans, P. W. M., Adrian, P. v., Albert, C., Estevão, S., Hoogenboezem, T., Luijendijk, I. H. T., Kamphausen, T., & Hammerschmidt, S. (2006). The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization. Journal of Biological Chemistry, 281(2), 968–976. doi: 10.1074/jbc.M510014200
  12. Herold, S., von Wulffen, W., Steinmueller, M., Pleschka, S., Kuziel, W. A., Mack, M., Srivastava, M., Seeger, W., Maus, U. A., & Lohmeyer, J. (2006). Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: Impact of chemokines and adhesion molecules. The Journal of Immunology, 177(3), 1817–1824. doi: 10.4049/jimmunol.177.3.1817
  13. Hippenstiel, S., Opitz, B., Schmeck, B., & Suttorp, N. (2006). Lung epithelium as a sentinel and effector system in pneumonia – Molecular mechanisms of pathogen recognition and signal transduction. Respiratory Research, 7(1). doi: 10.1186/1465-9921-7-97
  14. Koch, M., Witzenrath, M., Reuter, C., Herma, M., Schütte, H., Suttorp, N., Collins, H., & Kaufmann, S. H. E. (2006). Role of local pulmonary IFN-γ expression in murine allergic airway inflammation. American Journal of Respiratory Cell and Molecular Biology, 35(2), 211–219. doi: 10.1165/rcmb.2005-0293OC
  15. Krüll, M., Bockstaller, P., Wuppermann, F. N., Klucken, A. C., Mühling, J., Schmeck, B., Seybold, J., Walter, C., Maass, M., Rosseau, S., Hegemann, J. H., Suttorp, N., & Hippenstiel, S. (2006). Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 34(3), 375–382. doi: 10.1165/rcmb.2004-0157OC
  16. Kuhnke, A., Welte, T., & Suttorp, N. (2006). Pneumonie – Erregerbasierte oder konstellationsbasierte Therapie? Internist, 47(SUPPL. 1).doi: 10.1007/s00108-006-1623-x
  17. Lück, P. C., & Steinert, M. (2006). Pathogenese, Diagnostik und Therapie der Legionella-Infektion. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 49(5), 439–449. doi: 10.1007/s00103-006-1254-3
  18. Maus, U. A., Janzen, S., Wall, G., Srivastava, M., Blackwell, T. S., Christman, J. W., Seeger, W., Welte, T., & Lohmeyer, J. (2006). Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. American Journal of Respiratory Cell and Molecular Biology, 35(2), 227–235. doi: 10.1165/rcmb.2005-0241OC
  19. N’Guessan, P. D., Hippenstiel, S., Etouem, M. O., Zahlten, J., Beermann, W., Lindner, D., Opitz, B., Witzenrath, M., Rosseau, S., Suttorp, N., & Schmeck, B. (2006). Streptococcus pneumoniae induced p38 MAPK- and NF-κB-dependent COX-2 expression in human lung epithelium. American Journal of Physiology – Lung Cellular and Molecular Physiology, 290(6). doi: 10.1152/ajplung.00383.2005
  20. Opitz, B., Püschel, A., Beermann, W., Hocke, A. C., Förster, S., Schmeck, B., van Laak, V., Chakraborty, T., Suttorp, N., & Hippenstiel, S. (2006). Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. The Journal of Immunology, 176(1), 484–490. doi: 10.4049/jimmunol.176.1.484
  21. Opitz, B., Vinzing, M., van Laak, V., Schmeck, B., Heine, G., Günther, S., Preissner, R., Slevogt, H., N’Guessan, P. D., Eitel, J., Goldmann, T., Flieger, A., Suttorp, N., & Hippenstiel, S. (2006). Legionella pneumophila induces IFNβ in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. Journal of Biological Chemistry, 281(47), 36173–36179. doi: 10.1074/jbc.M604638200
  22. Schmeck, B., Beermann, W., van Laak, V., Opitz, B., Hocke, A. C., Meixenberger, K., Eitel, J., Chakraborty, T., Schmidt, G., Barth, H., Suttorp, N., & Hippenstiel, S. (2006). Listeria monocytogenes induced Rac1-dependent signal transduction in endothelial cells. Biochemical Pharmacology, 72(11), 1367–1374. doi: 10.1016/j.bcp.2006.06.033
  23. Schmeck, B., Huber, S., Moog, K., Zahlten, J., Hocke, A. C., Opitz, B., Hammerschmidt, S., Mitchell, T. J., Kracht, M., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2006). Pneumococci induced TLR- and Rac1-dependent NF-κB-recruitment to the IL-8 promoter in lung epithelial cells. American Journal of Physiology – Lung Cellular and Molecular Physiology, 290(4). doi: 10.1152/ajplung.00271.2005
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2005
  1. Bergmann, S., Rohde, M., Preissner, K. T., & Hammerschmidt, S. (2005). The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration. Thrombosis and Haemostasis, 94(2), 304–311. doi: 10.1160/TH05-05-0369
  2. Hamann, L., Alexander, C., Stamme, C., Zähringer, U., & Schumann, R. R. (2005). Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. Infection and Immunity, 73(1), 193–200. doi: 10.1128/IAI.73.1.193-200.2005
  3. Hammerschmidt, S., Wolff, S., Hocke, A., Rosseau, S., Müller, E., & Rohde, M. (2005). Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infection and Immunity, 73(8), 4653–4667. doi: 10.1128/IAI.73.8.4653-4667.2005
  4. Hippenstiel, S. (2005). Interaktion pulmonaler Epithelzellen mit Streptococcus pneumoniae. Pneumologie, 59(12), 895–896.doi: 10.1055/s-2005-915609
  5. Kohlhammer, Y., Schwartz, M., Raspe, H., & Schäfer, T. (2005). Risikofaktoren für die ambulant erworbene pneumonie (Community Acquired Pneumonia): Eine systematische Übersichtsarbeit. Deutsche Medizinische Wochenschrift, 130(8), 381–386. doi: 10.1055/s-2005-863061
  6. Krüll, M., Maass, M., Suttorp, N., & Rupp, J. (2005). Chlamydophila pneumoniae mechanisms of target cell infection and activation. Thrombosis and Haemostasis, 94(2), 319–326. doi: 10.1160/TH05-04-0261
  7. Maus, U. A., Wellmann, S., Hampl, C., Kuziel, W. A., Srivastava, M., Mack, M., Everhart, M. B., Blackwell, T. S., Christman, J. W., Schlöndorff, D., Bohle, R. M., Seeger, W., & Lohmeyer, J. (2005). CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. American Journal of Physiology – Lung Cellular and Molecular Physiology, 288(2 32-2). doi: 10.1152/ajplung.00061.2004
  8. McNealy, T. L., Forsbach-Birk, V., Shi, C., & Marre, R. (2005). The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA. Journal of Bacteriology, 187(4), 1527–1532. doi: 10.1128/JB.187.4.1527-1532.2005
  9. N’Guessan, P. D., Schmeck, B., Ayim, A., Hocke, A. C., Brell, B., Hammerschmidt, S., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2005). Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thrombosis and Haemostasis, 94(2), 295–303. doi: 10.1160/TH04-12-0822
  10. Opitz, B., Förster, S., Hocke, A. C., Maass, M., Schmeck, B., Hippenstiel, S., Suttorp, N., & Krüll, M. (2005). Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circulation Research, 96(3), 319–326. doi: 10.1161/01.RES.0000155721.83594.2c
  11. Pletz, M. W. R. (2005). Ambulant erworbene Pneumonie: Häufige Erreger und Antibiotikaresistenz. Pneumologe, 2(1), 17–27. doi: 10.1007/s10405-004-0019-7
  12. Reinert, R. R., Haupts, S., van der Linden, M., Heeg, C., Cil, M. Y., Al-Lahham, A., & Fedson, D. S. (2005). Invasive pneumococcal disease in adults in North-Rhine Westphalia, Germany, 2001-2003. Clinical Microbiology and Infection, 11(12), 985–991. doi: 10.1111/j.1469-0691.2005.01282.x
  13. Reinert, R. R., Ringelstein, A., van der Linden, M., Cil, M. Y., Al-Lahham, A., & Schmitz, F. J. (2005). Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe. Journal of Clinical Microbiology, 43(3), 1294–1300.doi: 10.1128/JCM.43.3.1294-1300.2005
  14. Rosseau, S. (2005). Pneumokokkenpneumonie im Mausmodell. Pneumologie, 59(6), 419–420. doi: 10.1055/s-2004-830314
  15. Rosseau, S., Wiechmann, K., Moderer, S., Selhorst, J., Mayer, K., Krüll, M., Hocke, A., Slevogt, H., Seeger, W., Suttorp, N., Seybold, J., & Lohmeyer, J. (2005). Moraxella catarrhalis-infected alveolar epithelium induced monocyte recruitment and oxidative burst. American Journal of Respiratory Cell and Molecular Biology, 32(2), 157–166. doi: 10.1165/rcmb.2004-0091OC
  16. Schmeck, B., Beermann, W., van Laak, V., Zahlten, J., Opitz, B., Witzenrath, M., Hocke, A. C., Chakraborty, T., Kracht, M., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2005). Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification. The Journal of Immunology, 175(5), 2843–2850. doi: 10.4049/jimmunol.175.5.2843
  17. Schröder, N. W. J., Diterich, I., Zinke, A., Eckert, J., Draing, C., Baehr, V. v., Hassler, D., Priem, S., Hahn, K., Michelsen, K. S., Hartung, T., Burmester, G. R., Göbel, U. B., Hermann, C., & Schumann, R. R. (2005). Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. The Journal of Immunology, 175(4), 2534–2540. doi: 10.4049/jimmunol.175.4.2534
  18. Schröder, N. W. J., Meister, D., Wolff, V., Christan, C., Kaner, D., Haban, V., Purucker, P., Hermann, C., Moter, A., Göbel, U. B., & Schumann, R. R. (2005). Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene. Genes and Immunity, 6(5), 448–451. doi: 10.1038/sj.gene.6364221
  19. Seybold, J., Thomas, D., Witzenrath, M., Boral, Ş., Hocke, A. C., Bürger, A., Hatzelmann, A., Tenor, H., Schudt, C., Krüll, M., Schütte, H., Hippenstiel, S., & Suttorp, N. (2005). Tumor necrosis factor-α-dependent expression of phosphodiesterase 2: Role in endothelial hyperpermeability. Blood, 105(9), 3569–3576. doi: 10.1182/blood-2004-07-2729
  20. Srivastava, M., Jung, S., Wilhelm, J., Fink, L., Bühling, F., Welte, T., Bohle, R. M., Seeger, W., Lohmeyer, J., & Maus, U. A. (2005). The Inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice Is associated with drastic changes in their gene expression profiles. The Journal of Immunology, 175(3), 1884–1893. doi: 10.4049/jimmunol.175.3.1884
  21. Welte, T., Marre, R., & Suttorp, N. (2005). Was gibt es neues in der Behandlung der ambulant erworbenen Pneumonie? Internist, 46(12), 1354–1359. doi: 10.1007/s00108-005-1524-4
2004
  1. Bergmann, S., Rohde, M., & Hammerschmidt, S. (2004). Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein. Infection and Immunity, 72(4), 2416–2419. doi: 10.1128/IAI.72.4.2416-2419.2004
  2. Elm, C., Braathen, R., Bergmann, S., Frank, R., Vaerman, J. P., Kaetzel, C. S., Chhatwal, G. S., Johansen, F. E., & Hammerschmidt, S. (2004). Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (HpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. Journal of Biological Chemistry, 279(8), 6296–6304. doi: 10.1074/jbc.M310528200
  3. Forsbach-Birk, V., McNealy, T., Shi, C., Lynch, D., & Marre, R. (2004). Reduced expression of the global regulator protein CsrA in Legionella pneumophila affects virulence-associated regulators and growth in Acanthamoeba castellanii. International Journal of Medical Microbiology, 294(1), 15–25. doi: 10.1016/j.ijmm.2003.12.003
  4. Hallatschek, W., Fiedler, G., Kirschning, C. J., Creutzburg, F., Lamping, N., Nüssler, A., & Schumann, R. R. (2004). Inhibition of hepatic transcriptional induction of lipopolysaccharide-binding protein by transforming-growth-factor β1. European Journal of Immunology, 34(5), 1441–1450. doi: 10.1002/eji.200324874
  5. Hamann, L., Hamprecht, A., Gomma, A., & Schumann, R. R. (2004). Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. Journal of Immunological Methods, 285(2), 281–291. doi: 10.1016/j.jim.2003.12.005
  6. Hamann, L., Kumpf, O., Müller, M., Visintin, A., Eckert, J., Schlag, P. M., & Schumann, R. R. (2004). A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling. Genes and Immunity, 5(4), 283–288.doi: 10.1038/sj.gene.6364068
  7. Hermann, C., Gueinzius, K., Oehme, A., von Aulock, S., Straube, E., & Hartung, T. (2004). Comparison of quantitative and semiquantitative enzyme-linked immunosorbent assays for immunoglobulin G against Chlamydophila pneumoniae to a microimmunofluorescence test for use with patients with respiratory tract infections. Journal of Clinical Microbiology, 42(6), 2476–2479. doi: 10.1128/JCM.42.6.2476-2479.2004
  8. Igel, L., Helbig, J. H., & Lück, P. C. (2004). Isolation and characterization of a nonfluorescent strain of Legionella parisiensis. Journal of Clinical Microbiology, 42(6), 2877–2878. doi: 10.1128/JCM.42.6.2877-2878.2004
  9. Krüll, M., Kramp, J., Petrov, T., Klucken, A. C., Hocke, A. C., Walter, C., Schmeck, B., Seybold, J., Maass, M., Ludwig, S., Kuipers, J. G., Suttorp, N., & Hippenstiel, S. (2004). Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells. Infection and Immunity, 72(11), 6615–6621. doi: 10.1128/IAI.72.11.6615-6621.2004
  10. Lück, P. C., Igel, L., Helbig, J. H., Kuhlisch, E., & Jatzwauk, L. (2004). Comparison of commercially available media for the recovery of Legionella species. International Journal of Hygiene and Environmental Health, 207(6), 589–593. doi: 10.1078/1438-4639-00332
  11. Marre, R., & von Baum, H. (2004). Welche Erreger machen krank bei der ambulant erworbenen Pneumonie? Die Medizinische Welt, 55(10), 319–321.
  12. Maus, U. A., Srivastava, M., Paton, J. C., Mack, M., Everhart, M. B., Blackwell, T. S., Christman, J. W., Schlöndorff, D., Seeger, W., & Lohmeyer, J. (2004). Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. The Journal of Immunology, 173(2), 1307–1312.  doi: 10.4049/jimmunol.173.2.1307
  13. Opitz, B., Püschel, A., Schmeck, B., Hocke, A. C., Rosseau, S., Hammerschmidt, S., Schumann, R. R., Suttorp, N., & Hippenstiel, S. (2004). Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. Journal of Biological Chemistry, 279(35), 36426–36432. doi: 10.1074/jbc.M403861200
  14. Reinert, R. R. (2004). Bedeutung von Pneumokokken bei der ambulant erworbenen Pneumonie (CAP). Die Medizinische Welt, 55(10), 322–326.
  15. Reinert, R. R., Franken, C., van der Linden, M., Lütticken, R., Cil, M., & Al-Lahham, A. (2004). Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003. International Journal of Antimicrobial Agents, 24(1), 43–47. doi: 10.1016/j.ijantimicag.2004.02.020
  16. Rödel, J., Prochnau, D., Prager, K., Baumert, J., Schmidt, K. H., & Straube, E. (2004). Chlamydia pneumoniae decreases smooth muscle cell proliferation through induction of prostaglandin E2 synthesis. Infection and Immunity, 72(8), 4900–4904. doi: 10.1128/IAI.72.8.4900-4904.2004
  17. Rosseau, S., Schmeck, B., & Suttorp, N. (2004). Pathogenese der Pneumonie. Die Medizinische Welt, 55(10), 337–341.
  18. Rupp, J., Droemann, D., Goldmann, T., Zabel, P., Solbach, W., Vollmer, E., Branscheid, D., Dalhoff, K., & Maass, M. (2004). Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection. FEMS Immunology and Medical Microbiology, 41(3), 197–203. doi: 10.1016/j.femsim.2004.03.004
  19. Schmeck, B., Gross, R., N’Guessan, P. D., Hocke, A. C., Hammerschmidt, S., Mitchell, T. J., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2004). Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and Immunity, 72(9), 4940–4947. doi: 10.1128/IAI.72.9.4940-4947.2004
  20. Schmeck, B., Zahlten, J., Moog, K., van Laak, V., Huber, S., Hocke, A. C., Opitz, B., Hoffmann, E., Kracht, M., Zerrahn, J., Hammerschmidt, S., Rosseau, S., Suttorp, N., & Hippenstiel, S. (2004). Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. Journal of Biological Chemistry, 279(51), 53241–53247. doi: 10.1074/jbc.M313702200
  21. Schmitz-Esser, S., Linka, N., Collingro, A., Beier, C. L., Neuhaus, H. E., Wagner, M., & Horn, M. (2004). ATP/ADP translocases: A common feature of obligate intracellular amoebal symbionts related to Chlamydiae and Rickettsiae. Journal of Bacteriology, 186(3), 683–691. doi: 10.1128/JB.186.3.683-691.2004
  22. Schröder, N. W. J., Heine, H., Alexander, C., Manukyan, M., Eckert, J., Hamann, L., Göbel, U. B., & Schumann, R. R. (2004). Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. The Journal of Immunology, 173(4), 2683–2691. doi: 10.4049/jimmunol.173.4.2683
  23. Schweiger, B. (2004). Viren als Ursache der ambulant erworbenen Pneumonie. Die Medizinische Welt, 55(10), 327–331.
  24. Walter, C., Zahlten, J., Schmeck, B., Schaudinn, C., Hippenstiel, S., Frisch, E., Hocke, A. C., Pischon, N., Kuramitsu, H. K., Bernimoulin, J. P., Suttorp, N., & Krüll, M. (2004). Porphyromonas gingivalis strain-dependent activation of human endothelial cells. Infection and Immunity, 72(10), 5910–5918. doi: 10.1128/IAI.72.10.5910-5918.2004
  25. Weber, M. (2004). Struktur der Informationstechnologie in einem Kompetenznetzwerk. Die Medizinische Welt, 55(10), 315–318.
  26. Welte, T. (2004). Therapie der ambulant erworbenen Pneumonie. Die Medizinische Welt, 55(10), 332–336.
  27. Welte, T., Marre, R., & Suttorp, N. (2004a). Das Kompetenznetzwerk “ambulant erworbene Pneumonie” (CAPNETZ). Internist, 45(4), 393–401.doi: 10.1007/s00108-004-1156-0
  28. Welte, T., Suttorp, N., & Marre, R. (2004). CAPNETZ – Community-acquired pneumonia competence network. Infection, 32(4), 234–238. doi: 10.1007/s15010-004-3107-z

2003

  1. Bergmann, S., Wild, D., Diekmann, O., Frank, R., Bracht, D., Chhatwal, G. S., & Hammerschmidt, S. (2003). Identification of a novel plasmin(ogen)-binding motif in surface displayed α-enolase of Streptococcus pneumoniae. Molecular Microbiology, 49(2), 411–423. doi: 10.1046/j.1365-2958.2003.03557.x

  2. Reinert, R. R., Muckel, S., Al-Lahham, A., Spratt, B. G., Brueggemann, A. B., Hakenbeck, R., & Lütticken, R. (2003). Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. Journal of Medical Microbiology, 52(11), 981–987. doi: 10.1099/jmm.0.05216-0

  3. Reischl, U., Lehn, N., Simnacher, U., Marre, R., & Essig, A. (2003). Rapid and standardized detection of Chlamydia pneumoniae using LightCycler real-time fluorescence PCR. European Journal of Clinical Microbiology and Infectious Diseases, 22(1), 54–57. doi: 10.1007/s10096-002-0858-2

  4. Schröder, N. W. J., Hermann, C., Hamann, L., Göbel, U. B., Hartung, T., & Schumann, R. R. (2003). High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. Journal of Molecular Medicine, 81(6), 368–372. doi: 10.1007/s00109-003-0443-x

  5. Schröder, N. W. J., Morath, S., Alexander, C., Hamann, L., Hartung, T., Zähringer, U., Göbel, U. B., Weber, J. R., & Schumann, R. R. (2003). Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. Journal of Biological Chemistry, 278(18), 15587–15594. doi: 10.1074/jbc.M212829200

  6. Tuschy, P., Welte, T., Marre, R., Suttorp, N., Lorenz, J., Fätkenheuer, G., & Ewig, S. (2003). SARS – Das schwere Akute Atemwegssyndrom. Pneumologie, 57(5), 256–258. doi: 10.1055/s-2003-39367

  7. Weber, J. R., Freyer, D., Alexander, C., Schröder, N. W. J., Reiss, A., Küster, C., Pfeil, D., Tuomanen, E. I., & Schumann, R. R. (2003). Recognition of pneumococcal peptidoglycan: An expanded, pivotal role for LPS-binding protein. Immunity, 19(2), 269–279. doi: 10.1016/S1074-7613(03)00205-X

  8. Welte, T., Marre, R., & Suttorp, N. (2003). CAPNetz-Kompetenznetzwerk ambulant erworbene Pneumonie: Strukturen und Ziele. Pneumologie, 57(1), 34–41. doi: 10.1055/s-2003-36635

2002

  1. Poppert, S., Essig, A., Marre, R., Wagner, M., & Horn, M. (2002). Detection and differentiation of Chlamydiae by fluorescence in situ hybridization. Applied and Environmental Microbiology, 68(8), 4081–4089. doi: 10.1128/AEM.68.8.4081-4089.2002

2001

  1. Horn, M., & Wagner, M. (2001). Evidence for additional genus-level diversity of Chlamydiales in the environment. FEMS Microbiology Letters, 204(1), 71–74. doi: 10.1111/j.1574-6968.2001.tb10865.x

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CAPNETZ STIFTUNG

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Medizinische Hochschule Hannover

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30625 Hannover 

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