PROGRESS Publications

2020

  1. Gesell Salazar, M., Neugebauer, S., Kacprowski, T., Michalik, S., Ahnert, P., Creutz, P., Rosolowski, M., Löffler, M., Bauer, M., Suttorp, N., Kiehntopf, M., & Völker, U. (2020). Association of proteome and metabolome signatures with severity in patients with community-acquired pneumonia. Journal of Proteomics, 214, 103627. doi: 10.1016/J.JPROT.2019.103627

  2. Müller-Redetzky, H., Kellermann, U., Wienhold, S. M., Gutbier, B., Lienau, J., Hellwig, K., Reppe, K., Letsiou, E., Tschernig, T., Scholz, M., Ahnert, P., Maasch, C., Hoehlig, K., Klussmann, S., Vater, A., Firsching, T. C., Hoppe, J., Suttorp, N., & Witzenrath, M. (2020). Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis. Anesthesiology, 132(4), 795–807. doi: 10.1097/ALN.0000000000003149

  3. Przybilla, J., Ahnert, P., Bogatsch, H., Bloos, F., Brunkhorst, F. M., Bauer, M., Loeffler, M., Witzenrath, M., Suttorp, N., & Scholz, M. (2020). Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. Journal of Clinical Medicine, 9(2), 393. doi: 10.3390/JCM9020393
2019
  1. Ahnert, P., Creutz, P., Horn, K., Schwarzenberger, F., Kiehntopf, M., Hossain, H., Bauer, M., Brunkhorst, F. M., Reinhart, K., Völker, U., Chakraborty, T., Witzenrath, M., Löffler, M., Suttorp, N., & Scholz, M. (2019). Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study. Critical Care (London, England), 23(1). doi: 10.1186/S13054-019-2316-X
2018
  1. Gutbier, B., Neuhauß, A. K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., & Witzenrath, M. (2018). Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. American Journal of Respiratory and Critical Care Medicine, 198(2), 220–231. doi: 10.1164/RCCM.201708-1733OC
2017
  1. Oak, P., Pritzke, T., Thiel, I., Koschlig, M., Mous, D. S., Windhorst, A., Jain, N., Eickelberg, O., Foerster, K., Schulze, A., Goepel, W., Reicherzer, T., Ehrhardt, H., Rottier, R. J., Ahnert, P., Gortner, L., Desai, T. J., & Hilgendorff, A. (2017). Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease. EMBO Molecular Medicine, 9(11), 1504–1520. doi: 10.15252/EMMM.201607308

2016

  1. Scherag, A., Schöneweck, F., Kesselmeier, M., Taudien, S., Platzer, M., Felder, M., Sponholz, C., Rautanen, A., Hill, A. V. S., Hinds, C. J., Hossain, H., Suttorp, N., Kurzai, O., Slevogt, H., Giamarellos-Bourboulis, E. J., Armaganidis, A., Trips, E., Scholz, M., & Brunkhorst, F. M. (2016). Genetic factors of the disease course after sepsis: A genome-wide study for 28-Day mortality. EBioMedicine, 12, 239–246. doi: 10.1016/J.EBIOM.2016.08.043

  2. Ahnert, P., Creutz, P., Scholz, M., Schütte, H., Engel, C., Hossain, H., Chakraborty, T., Bauer, M., Kiehntopf, M., Völker, U., Hammerschmidt, S., Loeffler, M., Suttorp, N., Liebrich, A., Ingrid Maria Stelzmüller, Khanavkar, B., Avdic, A., Wehde, D., Hauptmeier, B., … Lies, A. (2016). PROGRESS – prospective observational study on hospitalized community acquired pneumonia. BMC Pulmonary Medicine, 16(1). doi: 10.1186/S12890-016-0255-8

2014

  1. Press, A. T., Traeger, A., Pietsch, C., Mosig, A., Wagner, M., Clemens, M. G., Jbeily, N., Koch, N., Gottschaldt, M., Bézière, N., Ermolayev, V., Ntziachristos, V., Popp, J., Kessels, M. M., Qualmann, B., Schubert, U. S., & Bauer, M. (2014). Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. Nature Communications, 5. doi: 10.1038/NCOMMS6565

  2. Müller-Redetzky, H. C., Will, D., Hellwig, K., Kummer, W., Tschernig, T., Pfeil, U., Paddenberg, R., Menger, M. D., Kershaw, O., Gruber, A. D., Weissmann, N., Hippenstiel, S., Suttorp, N., & Witzenrath, M. (2014). Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Critical Care (London, England), 18(2). doi: 10.1186/CC13830

2013

  1. Knepper, J., Schierhorn, K. L., Becher, A., Budt, M., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Gruber, A. D., Suttorp, N., Schweiger, B., Hippenstiel, S., Hocke, A. C., & Wolff, T. (2013). The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue. MBio, 4(5). doi: 10.1128/MBIO.00601-13

  2. Hocke, A. C., Becher, A., Knepper, J., Peter, A., Holland, G., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Muth, D., Wendtner, C. M., Rückert, J. C., Drosten, C., Gruber, A. D., Laue, M., Suttorp, N., Hippenstiel, S., & Wolff, T. (2013). Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs. American Journal of Respiratory and Critical Care Medicine, 188(7), 882–886. doi: 10.1164/RCCM.201305-0954LE

  3. Hocke, A. C., Berg, J., Becher, A., Knepper, J., Klauschen, F., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Gruber, A. D., Suttorp, N., Hippenstiel, S., & Wolff, T. (2013). Reply to Fujino et al. The Journal of Infectious Diseases, 207(4), 693–695. doi: 10.1093/INFDIS/JIS740

  4. Doehn, J. M., Fischer, K., Reppe, K., Gutbier, B., Tschernig, T., Hocke, A. C., Fischetti, V. A., Löffler, J., Suttorp, N., Hippenstiel, S., & Witzenrath, M. (2013). Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. The Journal of Antimicrobial Chemotherapy, 68(9), 2111–2117. doi: 10.1093/JAC/DKT131

  5. Zahlten, J., Steinicke, R., Bertrams, W., Hocke, A. C., Scharf, S., Schmeck, B., Witzenrath, M., Hammerschmidt, S., Suttorp, N., & Hippenstiel, S. (2013). TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia. The European Respiratory Journal, 41(2), 384–391. doi: 10.1183/09031936.00196311

2012

  1. Weinheimer, V. K., Becher, A., Tönnies, M., Holland, G., Knepper, J., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Szymanski, K., Temmesfeld-Wollbrueck, B., Gruber, A. D., Bannert, N., Suttorp, N., Hippenstiel, S., Wolff, T., & Hocke, A. C. (2012). Influenza A viruses target type II pneumocytes in the human lung. The Journal of Infectious Diseases, 206(11), 1685–1694. doi: 10.1093/INFDIS/JIS455

  2. Szymanski, K. v., Toennies, M., Becher, A., Fatykhova, D., N’Guessan, P. D., Gutbier, B., Klauschen, F., Neuschaefer-Rube, F., Schneider, P., Rueckert, J., Neudecker, J., Bauer, T. T., Dalhoff, K., Drom̈ann, D., Gruber, A. D., Kershaw, O., Temmesfeld-Wollbrueck, B., Suttorp, N., Hippenstiel, S., & Hocke, A. C. (2012). Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue. The European Respiratory Journal, 40(6), 1458–1467. doi: 10.1183/09031936.00186911

  3. Weber, M., Lambeck, S., Ding, N., Henken, S., Kohl, M., Deigner, H. P., Enot, D. P., Igwe, E. I., Frappart, L., Kiehntopf, M., Claus, R. A., Kamradt, T., Weih, D., Vodovotz, Y., Briles, D. E., Ogunniyi, A. D., Paton, J. C., Maus, U. A., & Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 26(6), 2424–2436. doi: 10.1096/FJ.11-191957

  4. Scharf, S., Zahlten, J., Szymanski, K., Hippenstiel, S., Suttorp, N., & N’Guessan, P. D. (2012). Streptococcus pneumoniae induces human β-defensin-2 and -3 in human lung epithelium. Experimental Lung Research, 38(2), 100–110. doi: 10.3109/01902148.2011.652802
2011
  1. Lorenz, J., Zahlten, J., Pollok, I., Lippmann, J., Scharf, S., N’Guessan, P. D., Opitz, B., Flieger, A., Suttorp, N., Hippenstiel, S., & Schmeck, B. (2011). Legionella pneumophila-induced IκBζ-dependent expression of interleukin-6 in lung epithelium. The European Respiratory Journal, 37(3), 648–657. doi: 10.1183/09031936.00200009

2010

  1. Müller, H. C., Hellwig, K., Rosseau, S., Tschernig, T., Schmiedl, A., Gutbier, B., Schmeck, B., Hippenstiel, S., Peters, H., Morawietz, L., Suttorp, N., & Witzenrath, M. (2010). Simvastatin attenuates ventilator-induced lung injury in mice. Critical Care (London, England), 14(4). doi: 10.1186/CC9209

  2. Müller, H. C., Witzenrath, M., Tschernig, T., Gutbier, B., Hippenstiel, S., Santel, A., Suttorp, N., & Rosseau, S. (2010). Adrenomedullin attenuates ventilator-induced lung injury in mice. Thorax, 65(12), 1077–1084. doi: 10.1136/THX.2010.135996

  3. Scharf, S., Hippenstiel, S., Flieger, A., Suttorp, N., & N’Guessan, P. D. (2010). Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1. American Journal of Physiology. Lung Cellular and Molecular Physiology, 298(5). doi: 10.1152/AJPLUNG.00365.2009

  4. Scharf, S., Vardarova, K., Lang, F., Schmeck, B., Opitz, B., Flieger, A., Heuner, K., Hippenstiel, S., Suttorp, N., & N’Guessan, P. D. (2010). Legionella pneumophila induces human beta defensin-3 in pulmonary cells. Respiratory Research, 11(1). doi: 10.1186/1465-9921-11-93

  5. Zahlten, J., Steinicke, R., Opitz, B., Eitel, J., N’Guessan, P. D., Vinzing, M., Witzenrath, M., Schmeck, B., Hammerschmidt, S., Suttorp, N., & Hippenstiel, S. (2010). TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression. Journal of Immunology (Baltimore, Md. : 1950), 185(1), 597–604. doi: 10.4049/JIMMUNOL.0901798

2009

  1. N’Guessan, P. D., Riediger, F., Vardarova, K., Scharf, S., Eitel, J., Opitz, B., Slevogt, H., Weichert, W., Hocke, A. C., Schmeck, B., Suttorp, N., & Hippenstiel, S. (2009). Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(3), 380–386. doi: 10.1161/ATVBAHA.108.178319

  2. Witzenrath, M., Schmeck, B., Doehn, J. M., Tschernig, T., Zahlten, J., Loeffler, J. M., Zemlin, M., Müller, H., Gutbier, B., Schütte, H., Hippenstiel, S., Fischetti, V. A., Suttorp, N., & Rosseau, S. (2009). Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Critical Care Medicine, 37(2), 642–649. doi: 10.1097/CCM.0B013E31819586A6

2008

  1. Eitel, J., Krüll, M., Hocke, A. C., N′Guessan, P. D., Zahlten, J., Schmeck, B., Slevogt, H., Hippenstiel, S., Suttorp, N., & Opitz, B. (2008). Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2. Journal of Immunology (Baltimore, Md. : 1950), 181(4), 2664–2671. doi: 10.4049/JIMMUNOL.181.4.2664

  2. Schmeck, B., Lorenz, J., N′Guessan, P. D., Opitz, B., van Laak, V., Zahlten, J., Slevogt, H., Witzenrath, M., Flieger, A., Suttorp, N., & Hippenstiel, S. (2008). Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. Journal of Immunology (Baltimore, Md. : 1950), 181(2), 940–947. doi: 10.4049/JIMMUNOL.181.2.940

  3. Hocke, A. C., Hartmann, I. K., Eitel, J., Optiz, B., Scharf, S., Suttorp, N., & Hippenstiel, S. (2008). Subcellular expression pattern and role of IL-15 in pneumococci induced lung epithelial apoptosis. Histochemistry and Cell Biology, 130(1), 165–176. doi: 10.1007/S00418-008-0414-Y

  4. Vinzing, M., Eitel, J., Lippmann, J., Hocke, A. C., Zahlten, J., Slevogt, H., N′Guessan, P. D., Günther, S., Schmeck, B., Hippenstiel, S., Flieger, A., Suttorp, N., & Opitz, B. (2008). NAIP and Ipaf control Legionella pneumophila replication in human cells. Journal of Immunology (Baltimore, Md. : 1950), 180(10), 6808–6815. doi: 10.4049/JIMMUNOL.180.10.6808

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