PROGRESS Publikationen
2020
- Gesell Salazar, M., Neugebauer, S., Kacprowski, T., Michalik, S., Ahnert, P., Creutz, P., Rosolowski, M., Löffler, M., Bauer, M., Suttorp, N., Kiehntopf, M., & Völker, U. (2020). Association of proteome and metabolome signatures with severity in patients with community-acquired pneumonia. Journal of Proteomics, 214, 103627. doi: 10.1016/J.JPROT.2019.103627
- Müller-Redetzky, H., Kellermann, U., Wienhold, S. M., Gutbier, B., Lienau, J., Hellwig, K., Reppe, K., Letsiou, E., Tschernig, T., Scholz, M., Ahnert, P., Maasch, C., Hoehlig, K., Klussmann, S., Vater, A., Firsching, T. C., Hoppe, J., Suttorp, N., & Witzenrath, M. (2020). Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis. Anesthesiology, 132(4), 795–807. doi: 10.1097/ALN.0000000000003149
- Przybilla, J., Ahnert, P., Bogatsch, H., Bloos, F., Brunkhorst, F. M., Bauer, M., Loeffler, M., Witzenrath, M., Suttorp, N., & Scholz, M. (2020). Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. Journal of Clinical Medicine, 9(2), 393. doi: 10.3390/JCM9020393
2019
- Ahnert, P., Creutz, P., Horn, K., Schwarzenberger, F., Kiehntopf, M., Hossain, H., Bauer, M., Brunkhorst, F. M., Reinhart, K., Völker, U., Chakraborty, T., Witzenrath, M., Löffler, M., Suttorp, N., & Scholz, M. (2019). Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study. Critical Care (London, England), 23(1). doi: 10.1186/S13054-019-2316-X
2018
- Gutbier, B., Neuhauß, A. K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., & Witzenrath, M. (2018). Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. American Journal of Respiratory and Critical Care Medicine, 198(2), 220–231. doi: 10.1164/RCCM.201708-1733OC
2017
- Oak, P., Pritzke, T., Thiel, I., Koschlig, M., Mous, D. S., Windhorst, A., Jain, N., Eickelberg, O., Foerster, K., Schulze, A., Goepel, W., Reicherzer, T., Ehrhardt, H., Rottier, R. J., Ahnert, P., Gortner, L., Desai, T. J., & Hilgendorff, A. (2017). Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease. EMBO Molecular Medicine, 9(11), 1504–1520. doi: 10.15252/EMMM.201607308
2016
- Scherag, A., Schöneweck, F., Kesselmeier, M., Taudien, S., Platzer, M., Felder, M., Sponholz, C., Rautanen, A., Hill, A. V. S., Hinds, C. J., Hossain, H., Suttorp, N., Kurzai, O., Slevogt, H., Giamarellos-Bourboulis, E. J., Armaganidis, A., Trips, E., Scholz, M., & Brunkhorst, F. M. (2016). Genetic factors of the disease course after sepsis: A genome-wide study for 28-Day mortality. EBioMedicine, 12, 239–246. doi: 10.1016/J.EBIOM.2016.08.043
- Ahnert, P., Creutz, P., Scholz, M., Schütte, H., Engel, C., Hossain, H., Chakraborty, T., Bauer, M., Kiehntopf, M., Völker, U., Hammerschmidt, S., Loeffler, M., Suttorp, N., Liebrich, A., Ingrid Maria Stelzmüller, Khanavkar, B., Avdic, A., Wehde, D., Hauptmeier, B., … Lies, A. (2016). PROGRESS – prospective observational study on hospitalized community acquired pneumonia. BMC Pulmonary Medicine, 16(1). doi: 10.1186/S12890-016-0255-8
2014
- Press, A. T., Traeger, A., Pietsch, C., Mosig, A., Wagner, M., Clemens, M. G., Jbeily, N., Koch, N., Gottschaldt, M., Bézière, N., Ermolayev, V., Ntziachristos, V., Popp, J., Kessels, M. M., Qualmann, B., Schubert, U. S., & Bauer, M. (2014). Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. Nature Communications, 5. doi: 10.1038/NCOMMS6565
- Müller-Redetzky, H. C., Will, D., Hellwig, K., Kummer, W., Tschernig, T., Pfeil, U., Paddenberg, R., Menger, M. D., Kershaw, O., Gruber, A. D., Weissmann, N., Hippenstiel, S., Suttorp, N., & Witzenrath, M. (2014). Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Critical Care (London, England), 18(2). doi: 10.1186/CC13830
2013
- Knepper, J., Schierhorn, K. L., Becher, A., Budt, M., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Gruber, A. D., Suttorp, N., Schweiger, B., Hippenstiel, S., Hocke, A. C., & Wolff, T. (2013). The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue. MBio, 4(5). doi: 10.1128/MBIO.00601-13
- Hocke, A. C., Becher, A., Knepper, J., Peter, A., Holland, G., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Muth, D., Wendtner, C. M., Rückert, J. C., Drosten, C., Gruber, A. D., Laue, M., Suttorp, N., Hippenstiel, S., & Wolff, T. (2013). Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs. American Journal of Respiratory and Critical Care Medicine, 188(7), 882–886. doi: 10.1164/RCCM.201305-0954LE
- Hocke, A. C., Berg, J., Becher, A., Knepper, J., Klauschen, F., Tönnies, M., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Gruber, A. D., Suttorp, N., Hippenstiel, S., & Wolff, T. (2013). Reply to Fujino et al. The Journal of Infectious Diseases, 207(4), 693–695. doi: 10.1093/INFDIS/JIS740
- Doehn, J. M., Fischer, K., Reppe, K., Gutbier, B., Tschernig, T., Hocke, A. C., Fischetti, V. A., Löffler, J., Suttorp, N., Hippenstiel, S., & Witzenrath, M. (2013). Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. The Journal of Antimicrobial Chemotherapy, 68(9), 2111–2117. doi: 10.1093/JAC/DKT131
- Zahlten, J., Steinicke, R., Bertrams, W., Hocke, A. C., Scharf, S., Schmeck, B., Witzenrath, M., Hammerschmidt, S., Suttorp, N., & Hippenstiel, S. (2013). TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia. The European Respiratory Journal, 41(2), 384–391. doi: 10.1183/09031936.00196311
2012
- Weinheimer, V. K., Becher, A., Tönnies, M., Holland, G., Knepper, J., Bauer, T. T., Schneider, P., Neudecker, J., Rückert, J. C., Szymanski, K., Temmesfeld-Wollbrueck, B., Gruber, A. D., Bannert, N., Suttorp, N., Hippenstiel, S., Wolff, T., & Hocke, A. C. (2012). Influenza A viruses target type II pneumocytes in the human lung. The Journal of Infectious Diseases, 206(11), 1685–1694. doi: 10.1093/INFDIS/JIS455
- Szymanski, K. v., Toennies, M., Becher, A., Fatykhova, D., N’Guessan, P. D., Gutbier, B., Klauschen, F., Neuschaefer-Rube, F., Schneider, P., Rueckert, J., Neudecker, J., Bauer, T. T., Dalhoff, K., Drom̈ann, D., Gruber, A. D., Kershaw, O., Temmesfeld-Wollbrueck, B., Suttorp, N., Hippenstiel, S., & Hocke, A. C. (2012). Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue. The European Respiratory Journal, 40(6), 1458–1467. doi: 10.1183/09031936.00186911
- Weber, M., Lambeck, S., Ding, N., Henken, S., Kohl, M., Deigner, H. P., Enot, D. P., Igwe, E. I., Frappart, L., Kiehntopf, M., Claus, R. A., Kamradt, T., Weih, D., Vodovotz, Y., Briles, D. E., Ogunniyi, A. D., Paton, J. C., Maus, U. A., & Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 26(6), 2424–2436. doi: 10.1096/FJ.11-191957
- Scharf, S., Zahlten, J., Szymanski, K., Hippenstiel, S., Suttorp, N., & N’Guessan, P. D. (2012). Streptococcus pneumoniae induces human β-defensin-2 and -3 in human lung epithelium. Experimental Lung Research, 38(2), 100–110. doi: 10.3109/01902148.2011.652802
2011
- Lorenz, J., Zahlten, J., Pollok, I., Lippmann, J., Scharf, S., N’Guessan, P. D., Opitz, B., Flieger, A., Suttorp, N., Hippenstiel, S., & Schmeck, B. (2011). Legionella pneumophila-induced IκBζ-dependent expression of interleukin-6 in lung epithelium. The European Respiratory Journal, 37(3), 648–657. doi: 10.1183/09031936.00200009
2010
- Müller, H. C., Hellwig, K., Rosseau, S., Tschernig, T., Schmiedl, A., Gutbier, B., Schmeck, B., Hippenstiel, S., Peters, H., Morawietz, L., Suttorp, N., & Witzenrath, M. (2010). Simvastatin attenuates ventilator-induced lung injury in mice. Critical Care (London, England), 14(4). doi: 10.1186/CC9209
- Müller, H. C., Witzenrath, M., Tschernig, T., Gutbier, B., Hippenstiel, S., Santel, A., Suttorp, N., & Rosseau, S. (2010). Adrenomedullin attenuates ventilator-induced lung injury in mice. Thorax, 65(12), 1077–1084. doi: 10.1136/THX.2010.135996
- Scharf, S., Hippenstiel, S., Flieger, A., Suttorp, N., & N’Guessan, P. D. (2010). Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1. American Journal of Physiology. Lung Cellular and Molecular Physiology, 298(5). doi: 10.1152/AJPLUNG.00365.2009
- Scharf, S., Vardarova, K., Lang, F., Schmeck, B., Opitz, B., Flieger, A., Heuner, K., Hippenstiel, S., Suttorp, N., & N’Guessan, P. D. (2010). Legionella pneumophila induces human beta defensin-3 in pulmonary cells. Respiratory Research, 11(1). doi: 10.1186/1465-9921-11-93
- Zahlten, J., Steinicke, R., Opitz, B., Eitel, J., N’Guessan, P. D., Vinzing, M., Witzenrath, M., Schmeck, B., Hammerschmidt, S., Suttorp, N., & Hippenstiel, S. (2010). TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression. Journal of Immunology (Baltimore, Md. : 1950), 185(1), 597–604. doi: 10.4049/JIMMUNOL.0901798
2009
- N’Guessan, P. D., Riediger, F., Vardarova, K., Scharf, S., Eitel, J., Opitz, B., Slevogt, H., Weichert, W., Hocke, A. C., Schmeck, B., Suttorp, N., & Hippenstiel, S. (2009). Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(3), 380–386. doi: 10.1161/ATVBAHA.108.178319
- Witzenrath, M., Schmeck, B., Doehn, J. M., Tschernig, T., Zahlten, J., Loeffler, J. M., Zemlin, M., Müller, H., Gutbier, B., Schütte, H., Hippenstiel, S., Fischetti, V. A., Suttorp, N., & Rosseau, S. (2009). Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Critical Care Medicine, 37(2), 642–649. doi: 10.1097/CCM.0B013E31819586A6
2008
- Eitel, J., Krüll, M., Hocke, A. C., N′Guessan, P. D., Zahlten, J., Schmeck, B., Slevogt, H., Hippenstiel, S., Suttorp, N., & Opitz, B. (2008). Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2. Journal of Immunology (Baltimore, Md. : 1950), 181(4), 2664–2671. doi: 10.4049/JIMMUNOL.181.4.2664
- Schmeck, B., Lorenz, J., N′Guessan, P. D., Opitz, B., van Laak, V., Zahlten, J., Slevogt, H., Witzenrath, M., Flieger, A., Suttorp, N., & Hippenstiel, S. (2008). Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. Journal of Immunology (Baltimore, Md. : 1950), 181(2), 940–947. doi: 10.4049/JIMMUNOL.181.2.940
- Hocke, A. C., Hartmann, I. K., Eitel, J., Optiz, B., Scharf, S., Suttorp, N., & Hippenstiel, S. (2008). Subcellular expression pattern and role of IL-15 in pneumococci induced lung epithelial apoptosis. Histochemistry and Cell Biology, 130(1), 165–176. doi: 10.1007/S00418-008-0414-Y
- Vinzing, M., Eitel, J., Lippmann, J., Hocke, A. C., Zahlten, J., Slevogt, H., N′Guessan, P. D., Günther, S., Schmeck, B., Hippenstiel, S., Flieger, A., Suttorp, N., & Opitz, B. (2008). NAIP and Ipaf control Legionella pneumophila replication in human cells. Journal of Immunology (Baltimore, Md. : 1950), 180(10), 6808–6815. doi: 10.4049/JIMMUNOL.180.10.6808